Title : Deletion of the Src homology 3 domain and C-terminal proline-rich sequences in Bcr-Abl prevents Abl interactor 2 degradation and spontaneous cell migration and impairs leukemogenesis.

Pub. Date : 2001 Aug 3

PMID : 11387320






2 Functional Relationships(s)
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1 Deletion of the Src homology 3 domain and C-terminal proline-rich sequences in Bcr-Abl prevents Abl interactor 2 degradation and spontaneous cell migration and impairs leukemogenesis. Proline ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 We report here that the Src homology 3 domain and C-terminal proline-rich sequences of Bcr-Abl are required for its binding to Abl interactor 2 as well as for the induction of Abl interactor 2 degradation. Proline ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens