Title : Increase of the photosensitizing efficiency of the Bacteriochlorin a by liposome-incorporation.

Pub. Date : 2001 Apr

PMID : 11386681






8 Functional Relationships(s)
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1 To describe the action mechanisms of Bacteriochlorin a (BCA), a second generation photosensitizer, in phosphate buffer (PB) and in dimyristoyl phosphatidylcholine (DMPC) liposomes we carried out oxygen consumption and ESR measurements. Dimyristoylphosphatidylcholine B cell linker Homo sapiens
2 To describe the action mechanisms of Bacteriochlorin a (BCA), a second generation photosensitizer, in phosphate buffer (PB) and in dimyristoyl phosphatidylcholine (DMPC) liposomes we carried out oxygen consumption and ESR measurements. Dimyristoylphosphatidylcholine B cell linker Homo sapiens
3 To describe the action mechanisms of Bacteriochlorin a (BCA), a second generation photosensitizer, in phosphate buffer (PB) and in dimyristoyl phosphatidylcholine (DMPC) liposomes we carried out oxygen consumption and ESR measurements. Dimyristoylphosphatidylcholine B cell linker Homo sapiens
4 To describe the action mechanisms of Bacteriochlorin a (BCA), a second generation photosensitizer, in phosphate buffer (PB) and in dimyristoyl phosphatidylcholine (DMPC) liposomes we carried out oxygen consumption and ESR measurements. Dimyristoylphosphatidylcholine B cell linker Homo sapiens
5 Incorporation of BCA in DMPC liposomes, by promoting the monomerization of BCA, increased 9-fold the oxygen consumption in comparison to the value in PB. Dimyristoylphosphatidylcholine B cell linker Homo sapiens
6 Incorporation of BCA in DMPC liposomes, by promoting the monomerization of BCA, increased 9-fold the oxygen consumption in comparison to the value in PB. Dimyristoylphosphatidylcholine B cell linker Homo sapiens
7 The use of specific singlet oxygen quenchers (Azide and 9,10-Anthracenedipropionic acid) in ESR and oxygen consumption experiments allowed us to assert that BCA was mainly a type II sensitizer when it was incorporated in DMPC. Dimyristoylphosphatidylcholine B cell linker Homo sapiens
8 Finally, the cell survival of WiDr cells after a PDT treatment was measured for cells incubated with BCA in cell culture medium and cells incubated with BCA in DMPC. Dimyristoylphosphatidylcholine B cell linker Homo sapiens