Title : Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction.

Pub. Date : 2001 Jun

PMID : 11383749






2 Functional Relationships(s)
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1 Minocycline- and saline-treated mice subjected to traumatic brain injury were compared with respect to neurological function, lesion volume, and interleukin-1beta production. Minocycline interleukin 1 beta Mus musculus
2 Caspase-1 activity, quantified by measuring mature interleukin-1beta production by enzyme-linked immunosorbent assay, was considerably increased in mice that underwent TBI, and this increase was significantly diminished in minocycline-treated mice. Minocycline interleukin 1 beta Mus musculus