Title : The antitumor mechanism of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)-cytosine: effects of its triphosphate on mammalian DNA polymerases.

Pub. Date : 2001 May

PMID : 11376566






1 Functional Relationships(s)
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1 We observed potent inhibitory action of the triphosphate of 4"-thio-FAC (4"-thio-FACTP) against DNA polymerase alpha, whereas it showed moderate inhibition of DNA polymerase beta and little inhibition of DNA polymerase gamma. triphosphoric acid FA complementation group C Homo sapiens