Title : Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers.

Pub. Date : 2001 Jun 1

PMID : 11376495






1 Functional Relationships(s)
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1 Treatment with NS-398 and Vioxx, which caused only a moderate decrease in the PGE(2) generation in the non-ulcerated gastric mucosa, delayed ulcer healing and attenuated significantly the GBF at ulcer margin and PGE(2) generation in the ulcerated tissue, while raising the plasma IL-1beta and TNFalpha similarly to those observed in indomethacin- and ASA-treated rats. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide tumor necrosis factor Rattus norvegicus