Title : Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4.

Pub. Date : 2001 Mar

PMID : 11367523






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Site directed mutagenesis experiments revealed that D1106 is responsible for the effective binding of C4A to form amide bonds with immune aggregates or protein antigens, and H1106 of C4B catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Esters complement C4A (Rodgers blood group) Homo sapiens