Title : Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.

Pub. Date : 2001 May

PMID : 11359930






1 Functional Relationships(s)
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1 Inhibition of proteasome activity resulted in a twofold increase in the amount of ubiquitinated, SDS-resistant aggregates, indicating that inclusion bodies accumulate when the capacity of the ubiquitin-proteasome system to degrade aggregation-prone huntingtin protein is exhausted. Sodium Dodecyl Sulfate huntingtin Homo sapiens