Pub. Date : 2001 May 15
PMID : 11358830
20 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Organ-specific activation of activator protein-1 in transgenic mice by 12-o-tetradecanoylphorbol-13-acetate with different administration methods. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 2 | injection), we analyzed TPA-stimulated activator protein-1 (AP-1) activity in various organs (liver, kidney, brain, lung, spleen, heart, stomach, colon, esophagus, and skin) from transgenic mice expressing the AP-1 luciferase reporter gene. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 3 | injection), we analyzed TPA-stimulated activator protein-1 (AP-1) activity in various organs (liver, kidney, brain, lung, spleen, heart, stomach, colon, esophagus, and skin) from transgenic mice expressing the AP-1 luciferase reporter gene. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 4 | Topical application of TPA by painting the skin on the back of mice raised AP-1 activity 122.6-fold, and the highest peak of AP-1 activity was at 12 h after administration of TPA. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 5 | Topical application of TPA by painting the skin on the back of mice raised AP-1 activity 122.6-fold, and the highest peak of AP-1 activity was at 12 h after administration of TPA. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 6 | Topical application of TPA by painting the skin on the back of mice raised AP-1 activity 122.6-fold, and the highest peak of AP-1 activity was at 12 h after administration of TPA. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 7 | Drinking water containing TPA caused a 25.8-fold induction of AP-1 activity in the skin, whereas gavage feeding with TPA caused a 34.2-fold induction of AP-1 in the skin. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 8 | Drinking water containing TPA caused a 25.8-fold induction of AP-1 activity in the skin, whereas gavage feeding with TPA caused a 34.2-fold induction of AP-1 in the skin. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 9 | injection of TPA induced a 49.56-fold or 20.4-fold increase in AP-1 activity in the skin, respectively. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 10 | The highest peaks of AP-1 activity in the skin were at 12 h after drinking, feeding, or injection of TPA. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 11 | injection of TPA raised AP-1 activity 13.9-fold, drinking TPA raised AP-1 activity 8.4-fold, and painting with TPA caused a 2.4-fold induction of AP-1 activity. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 12 | injection of TPA raised AP-1 activity 13.9-fold, drinking TPA raised AP-1 activity 8.4-fold, and painting with TPA caused a 2.4-fold induction of AP-1 activity. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 13 | injection of TPA raised AP-1 activity 13.9-fold, drinking TPA raised AP-1 activity 8.4-fold, and painting with TPA caused a 2.4-fold induction of AP-1 activity. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 14 | injection of TPA raised AP-1 activity 13.9-fold, drinking TPA raised AP-1 activity 8.4-fold, and painting with TPA caused a 2.4-fold induction of AP-1 activity. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 15 | injection of TPA raised AP-1 activity 13.9-fold, drinking TPA raised AP-1 activity 8.4-fold, and painting with TPA caused a 2.4-fold induction of AP-1 activity. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 16 | injection of TPA raised AP-1 activity 3.9-fold, drinking TPA induced a 1.2-fold increase in AP-1 activity, but painting with TPA had no effect. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 17 | injection of TPA raised AP-1 activity 3.9-fold, drinking TPA induced a 1.2-fold increase in AP-1 activity, but painting with TPA had no effect. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 18 | injection of TPA raised AP-1 activity 3.9-fold, drinking TPA induced a 1.2-fold increase in AP-1 activity, but painting with TPA had no effect. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 19 | These results indicate that the skin is the most sensitive organ to TPA induction of AP-1 activity. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 20 | The data suggest that the organ-specific, tumor-promoting effect of TPA may be through AP-1 activation and phosphorylation of ERKs and p38 kinase. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |