Title : Clinical concentrations of doxorubicin inhibit activity of myocardial membrane-associated, calcium-independent phospholipase A(2).

Pub. Date : 2001 May 15

PMID : 11358821






1 Functional Relationships(s)
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1 Addition of 0.1-10 microM doxorubicin to these cells led to a concentration- and time-dependent inhibition of total iPLA(2), as measured using (16:0, [(3)H]18:1) plasmenylcholine and phosphatidylcholine substrates in the presence or absence of calcium. Phosphatidylcholines phospholipase A2 group VI Rattus norvegicus