Pub. Date : 2001 May 16
PMID : 11353786
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells. | lysophosphatidic acid | vascular endothelial growth factor A | Homo sapiens |
| 2 | METHODS: VEGF expression was examined in a simian virus 40 T-antigen-immortalized ovarian surface epithelial cell line (IOSE-29) and in ovarian cancer cell lines (OVCAR-3, SKOV-3, and CAOV-3) treated with LPA. | lysophosphatidic acid | vascular endothelial growth factor A | Homo sapiens |
| 3 | RESULTS: LPA treatment increased steady-state VEGF messenger RNA (mRNA) levels in OVCAR-3 cells in a time- and dose-dependent fashion and stimulated VEGF promoter activity without prolonging mRNA half-life in these cells, but LPA had little effect on IOSE-29 cells. | lysophosphatidic acid | vascular endothelial growth factor A | Homo sapiens |
| 4 | RESULTS: LPA treatment increased steady-state VEGF messenger RNA (mRNA) levels in OVCAR-3 cells in a time- and dose-dependent fashion and stimulated VEGF promoter activity without prolonging mRNA half-life in these cells, but LPA had little effect on IOSE-29 cells. | lysophosphatidic acid | vascular endothelial growth factor A | Homo sapiens |