Title : Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells.

Pub. Date : 2001 May 16

PMID : 11353786






4 Functional Relationships(s)
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1 Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells. lysophosphatidic acid vascular endothelial growth factor A Homo sapiens
2 METHODS: VEGF expression was examined in a simian virus 40 T-antigen-immortalized ovarian surface epithelial cell line (IOSE-29) and in ovarian cancer cell lines (OVCAR-3, SKOV-3, and CAOV-3) treated with LPA. lysophosphatidic acid vascular endothelial growth factor A Homo sapiens
3 RESULTS: LPA treatment increased steady-state VEGF messenger RNA (mRNA) levels in OVCAR-3 cells in a time- and dose-dependent fashion and stimulated VEGF promoter activity without prolonging mRNA half-life in these cells, but LPA had little effect on IOSE-29 cells. lysophosphatidic acid vascular endothelial growth factor A Homo sapiens
4 RESULTS: LPA treatment increased steady-state VEGF messenger RNA (mRNA) levels in OVCAR-3 cells in a time- and dose-dependent fashion and stimulated VEGF promoter activity without prolonging mRNA half-life in these cells, but LPA had little effect on IOSE-29 cells. lysophosphatidic acid vascular endothelial growth factor A Homo sapiens