Title : Rat cytochrome p450 1A and 3A enzymes involved in bioactivation of tegafur to 5-fluorouracil and autoinduced by tegafur in liver microsomes.

Pub. Date : 2001 Jun

PMID : 11353746






1 Functional Relationships(s)
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1 Of 12 cDNA-expressed rat P450 enzymes tested, CYP1A2, CYP3A1, and CYP2C11 had high 5-FU formation rates from 100 microM and 1.0 mM tegafur concentrations. Tegafur cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus