Title : Increased release of arachidonic acid and eicosanoids in iron-overloaded cardiomyocytes.

Pub. Date : 2001 May 15

PMID : 11352890






1 Functional Relationships(s)
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1 Increased release of AA in iron-overloaded NRVMs was reduced by the diacylglycerol lipase inhibitor RHC80267 but was largely insensitive to inhibitors of phospholipases A(2) and C. Iron-overloaded cardiomyocytes also displayed increased production of eicosanoids and induction of cyclooxygenase-2 after stimulation with interleukin-1alpha. Iron interleukin 1 alpha Homo sapiens