Pub. Date : 2001 May
PMID : 11350830
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Selective induction of tissue inhibitor of metalloproteinase-1 in bleomycin-induced pulmonary fibrosis. | Bleomycin | tissue inhibitor of metalloproteinase 1 | Mus musculus |
| 2 | We demonstrate that TIMP-1 messenger RNA (mRNA) and protein expression are selectively and markedly increased in a murine model of bleomycin-induced pulmonary fibrosis. | Bleomycin | tissue inhibitor of metalloproteinase 1 | Mus musculus |
| 3 | Northern analysis showed that lung steady-state TIMP-1 mRNA levels increased 14-fold after bleomycin administration compared with control mice. | Bleomycin | tissue inhibitor of metalloproteinase 1 | Mus musculus |
| 4 | Metalloproteinase inhibitory activity of relative molecular mass of ~ 21 to 28 kD, corresponding to the molecular weights for TIMP-1 and TIMP-2, was identified in lung extracts of bleomycin-injured mice by reverse zymography. | Bleomycin | tissue inhibitor of metalloproteinase 1 | Mus musculus |
| 5 | Western analysis demonstrated that TIMP-1 protein levels in bronchoalveolar lavage fluid (BALF) of bleomycin-treated mice increased 220- and 151-fold at Days 4 and 28, respectively, compared with control mice. | Bleomycin | tissue inhibitor of metalloproteinase 1 | Mus musculus |
| 6 | These results demonstrate that TIMP-1 gene expression is selectively increased, and that the expression of TIMP-1 and TIMP-2 is differentially regulated in bleomycin-induced pulmonary fibrosis. | Bleomycin | tissue inhibitor of metalloproteinase 1 | Mus musculus |
| 7 | The profound and durable increase in TIMP-1 and TIMP-2 proteins suggests an important regulatory role for these antiproteases in the inflammatory and fibrotic responses to bleomycin-induced lung injury. | Bleomycin | tissue inhibitor of metalloproteinase 1 | Mus musculus |