Title : Molecular mechanisms of cell cycle block by methionine restriction in human prostate cancer cells.

Pub. Date : 2000

PMID : 11341037






1 Functional Relationships(s)
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1 Methionine restriction led to accumulation of the cyclin-dependent kinase inhibitors p21 and p27, as determined by Western blot analysis, and inhibited the enzymatic activities of the cyclin-dependent kinases CDK2 and cdc2, as determined by an in vitro kinase assay: However, methionine restriction had little or no effect on CDK2 or cdc2 protein levels. Methionine H3 histone pseudogene 16 Homo sapiens