Title : Histamine-induced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factor-alpha.

Pub. Date : 2001 May

PMID : 11336536






6 Functional Relationships(s)
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1 Histamine-induced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factor-alpha. Histamine interleukin 6 Homo sapiens
2 In this study, we tested the synergy between histamine and LPS, and histamine and TNF-alpha, on endothelial cell production of interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1). Histamine interleukin 6 Homo sapiens
3 In this study, we tested the synergy between histamine and LPS, and histamine and TNF-alpha, on endothelial cell production of interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1). Histamine interleukin 6 Homo sapiens
4 The incubation of HCAEC with histamine resulted in low level induction of IL-6 and IL-8 production, which was dose-dependent and attained a plateau at a concentration of 10 microM. Histamine interleukin 6 Homo sapiens
5 In the presence of all stimulatory concentrations of LPS and TNF-alpha tested, histamine was shown to further enhance IL-6 and IL-8 production. Histamine interleukin 6 Homo sapiens
6 Since both LPS and TNF-alpha potentiated histamine-induced cytokine production, it is possible that these activators stimulate H-1 receptor expression and/or augment the signal transduction pathways leading to the expression of IL-6 and IL-8. Histamine interleukin 6 Homo sapiens