Title : Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release.

Pub. Date : 2001 May 1

PMID : 11331615






1 Functional Relationships(s)
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1 The shift of the proteasomal components from the total cellular environment to the aggregates, as well as the comparatively slower degradation of tNhtt with longer polyglutamine, decreased the proteasome"s availability for degrading other key target proteins, such as p53. polyglutamine transformation related protein 53, pseudogene Mus musculus