Pub. Date : 2001 May
PMID : 11331423
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 2 | Addiction to nicotine may result in molecular adaptations in the neurocircuitry of specific brain structures via changes in the cyclic AMP-responsive element binding protein (CREB)-dependent gene transcription program. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 3 | Addiction to nicotine may result in molecular adaptations in the neurocircuitry of specific brain structures via changes in the cyclic AMP-responsive element binding protein (CREB)-dependent gene transcription program. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 4 | On the other hand, decreases in the expression of CREB protein and phosphorylation of CREB occur in the cingulate gyrus, and in the parietal and the piriform but not in the frontal cortex during nicotine withdrawal (18 h) after nicotine exposure. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 5 | On the other hand, decreases in the expression of CREB protein and phosphorylation of CREB occur in the cingulate gyrus, and in the parietal and the piriform but not in the frontal cortex during nicotine withdrawal (18 h) after nicotine exposure. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 6 | On the other hand, decreases in the expression of CREB protein and phosphorylation of CREB occur in the cingulate gyrus, and in the parietal and the piriform but not in the frontal cortex during nicotine withdrawal (18 h) after nicotine exposure. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 7 | On the other hand, decreases in the expression of CREB protein and phosphorylation of CREB occur in the cingulate gyrus, and in the parietal and the piriform but not in the frontal cortex during nicotine withdrawal (18 h) after nicotine exposure. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 8 | It was also observed that CREB and p-CREB protein levels were significantly decreased in the medial and basolateral, but not in the central amygdala during nicotine withdrawal (18 h) after chronic nicotine exposure. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 9 | It was also observed that CREB and p-CREB protein levels were significantly decreased in the medial and basolateral, but not in the central amygdala during nicotine withdrawal (18 h) after chronic nicotine exposure. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 10 | It was also observed that CREB and p-CREB protein levels were significantly decreased in the medial and basolateral, but not in the central amygdala during nicotine withdrawal (18 h) after chronic nicotine exposure. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 11 | It was also observed that CREB and p-CREB protein levels were significantly decreased in the medial and basolateral, but not in the central amygdala during nicotine withdrawal (18 h) after chronic nicotine exposure. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 12 | These results provide the first evidence that decreased CREB activity and/or expression in specific cortical and amygdaloid brain structures may be involved in the underlying molecular mechanisms of nicotine dependence. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |