Title : Reduction of carbon tetrachloride-induced rat liver injury by IRFI 042, a novel dual vitamin E-like antioxidant.

Pub. Date : 2001 Apr

PMID : 11328674






1 Functional Relationships(s)
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1 Carbon tetrachloride (CCl4 )-induced hepatotoxicity is likely the result of a CCl4 -induced free radical production which causes membrane lipid peroxidation and activation of transcription factors regulating both the TNF-alpha gene and the early-immediate genes involved in tissue regeneration. Free Radicals tumor necrosis factor Rattus norvegicus