Title : Double-edged sword of chemosensitizer: increase of multidrug resistance protein (MRP) in leukemic cells by an MRP inhibitor probenecid.

Pub. Date : 2001 Apr 27

PMID : 11322768






1 Functional Relationships(s)
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1 This study attempted not only to determine novel resistance mechanisms in MRP-overexpressing AML cells (AML-2/DX100) by chronic exposure to doxorubicin in the presence of an MRP inhibitor probenecid but also to find out whether probenecid could increase MRP levels. Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens