Pub. Date : 2000 Dec
PMID : 11321524
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P-glycoprotein, glutathione and glutathione S-transferase increase in a colon carcinoma cell line by colchicine. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | We developed a study aiming to evaluate the evolution of the main drug resistance markers in tumour cells: P-gly, GSH and GST, during the acquisition of resistance to colchicine, for the purpose of studying the adaptation process and its contribution to the MDR phenomenon. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | A human colon adenocarcinoma cell line was exposed to colchicine during 82 days, being P-gly, GSH levels and GST activity evaluated by flow cytometry, spectrofluorimetry and spectrophotometry, during exposure time. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | P-gly and GSH levels increased gradually during the exposure to colchicine, reaching 2.35 and 3.21 fold each. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |