Title : Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines.

Pub. Date : 2001 Jan 25

PMID : 11313973






3 Functional Relationships(s)
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1 By prolonged nocodazole treatment, U251MG human glioma cell, which has a p53 mutation, underwent transient arrest at mitosis, and subsequently exited from mitotic arrest (termed "mitotic slippage") followed by DNA replication without cytokinesis, resulting in hyperploid formation. Nocodazole tumor protein p53 Homo sapiens
2 By employing LN382 glioma cell that has a temperature-sensitive p53 mutation, we found that the activation of p53 prevents hyperploid formation after the prolonged nocodazole treatment. Nocodazole tumor protein p53 Homo sapiens
3 By employing LN382 glioma cell that has a temperature-sensitive p53 mutation, we found that the activation of p53 prevents hyperploid formation after the prolonged nocodazole treatment. Nocodazole tumor protein p53 Homo sapiens