Title : Evidence that wild-type p53 in neuroblastoma cells is in a conformation refractory to integration into the transcriptional complex.

Pub. Date : 2001 Mar 15

PMID : 11313875






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Nuclear accumulation of p53 was induced in NB cells using substances which disturb p53"s tertiary structure at its zinc finger motif, or by treatment with mitomycin C. Mitomycin tumor protein p53 Homo sapiens
2 Even though p53 showed DNA-binding capability after mitomycin C treatment of NB cells, the target gene products MDM2 and p21(WAF1,CIP1,SDI1) were not synthesized and no p53 transactivating activity measured in a reporter gene assay. Mitomycin tumor protein p53 Homo sapiens