Title : The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions.

Pub. Date : 2001 Apr

PMID : 11309550






1 Functional Relationships(s)
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1 In vitro, Bsep-mediated taurocholate transport was inhibited by bosentan (inhibition constant, approximately 12 micromol/L) and metabolites (inhibition constant, approximately 8.5 micromol/L for metabolite Ro 47-8634). Taurocholic Acid ATP binding cassette subfamily B member 11 Homo sapiens