Title : IGF-II down regulation associated cell cycle arrest in colon cancer cells exposed to phenolic antioxidant ellagic acid.

Pub. Date : 2001 Jan-Feb

PMID : 11299762






1 Functional Relationships(s)
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1 Collectively, these observations suggest that growth inhibition by ellagic acid is mediated by signaling pathways that mediate DNA damage, triggers p53, which in turn activates p21 and at the same time alters the growth factor expression, resulting in the down regulation of IGF-II. Ellagic Acid tumor protein p53 Homo sapiens