Title : Manganese superoxide dismutase signals matrix metalloproteinase expression via H2O2-dependent ERK1/2 activation.

Pub. Date : 2001 Apr 27

PMID : 11297530






2 Functional Relationships(s)
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1 Sod2-dependent increases in the steady-state levels of H(2)O(2) led to ERK1/2 activation and subsequent downstream transcriptional increases in matrix metalloproteinase-1 (MMP-1) expression, which were reversed by expression of the H(2)O(2)-detoxifying enzyme, catalase. Hydrogen Peroxide superoxide dismutase 2, mitochondrial Mus musculus
2 Sod2-dependent increases in the steady-state levels of H(2)O(2) led to ERK1/2 activation and subsequent downstream transcriptional increases in matrix metalloproteinase-1 (MMP-1) expression, which were reversed by expression of the H(2)O(2)-detoxifying enzyme, catalase. Hydrogen Peroxide superoxide dismutase 2, mitochondrial Mus musculus