Title : Non-steroidal anti-inflammatory drugs protect against chondrocyte apoptotic death.

Pub. Date : 2001

PMID : 11296547






1 Functional Relationships(s)
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1 Pre-treatment of the cultures with nimesulide, a preferential cyclooxygenase (COX)-2 inhibitor, or with ibuprofen, a non-selective COX-1/COX-2 inhibitor, protected the chondrocytes against the staurosporine-mediated nuclear damage and cell death in a concentration-dependent manner (10(-12) to 10(-6) M). Ibuprofen mitochondrially encoded cytochrome c oxidase II Homo sapiens