Title : Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis.

Pub. Date : 2001 Jun 22

PMID : 11294857






1 Functional Relationships(s)
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1 The hypoxia-dependent protection from apoptosis correlates with activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, which is detected after 3-4 h of hypoxic or deferoxamine treatment and is sustained while hypoxic conditions are maintained. Deferoxamine AKT serine/threonine kinase 1 Rattus norvegicus