Title : Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Pub. Date : 2001 Apr 20

PMID : 11292861






1 Functional Relationships(s)
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1 Here we show that the interaction between human pVHL and a specific domain of the HIF-1alpha subunit is regulated through hydroxylation of a proline residue (HIF-1alpha P564) by an enzyme we have termed HIF-alpha prolyl-hydroxylase (HIF-PH). Proline von Hippel-Lindau tumor suppressor Homo sapiens