Title : Limited signal transduction repertoire of human Y(5) neuropeptide Y receptors expressed in HEC-1B cells.

Pub. Date : 2001 Mar

PMID : 11287093






3 Functional Relationships(s)
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Protein Name
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1 In HEC-1B cells transfected with human Y(5) neuropeptide Y (NPY) receptors (but not in non-transfected cells) NPY inhibited forskolin-stimulated cAMP accumulation in a pertussis toxin-sensitive manner (-log EC(50) 8.88 +/- 0.25). Cyclic AMP neuropeptide Y Homo sapiens
2 In HEC-1B cells transfected with human Y(5) neuropeptide Y (NPY) receptors (but not in non-transfected cells) NPY inhibited forskolin-stimulated cAMP accumulation in a pertussis toxin-sensitive manner (-log EC(50) 8.88 +/- 0.25). Cyclic AMP neuropeptide Y Homo sapiens
3 We conclude that at least upon expression in HEC-1B cells the signal transduction of Y(5) NPY receptors is limited to inhibition of cAMP accumulation. Cyclic AMP neuropeptide Y Homo sapiens