Pub. Date : 2001 Apr 15
PMID : 11286989
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In addition, genistein enhanced the expression of the cell cycle inhibitor p21(waf/cip1) by 10- to 15-fold, increased p21(waf/cip1) association with Cdc2 by 2-fold, and increased the expression of the tumor suppressor p53 by 2.8-fold. | Genistein | H3 histone pseudogene 16 | Homo sapiens |
2 | In addition, genistein enhanced the expression of the cell cycle inhibitor p21(waf/cip1) by 10- to 15-fold, increased p21(waf/cip1) association with Cdc2 by 2-fold, and increased the expression of the tumor suppressor p53 by 2.8-fold. | Genistein | H3 histone pseudogene 16 | Homo sapiens |
3 | From these results, we conclude that genistein inhibits the growth of nonneoplastic MCF-10F human breast cells by preventing the G2/M phase transition, induces the expression of the cell cycle inhibitor p21(waf/cip1) as well as its interaction with Cdc2, and inhibits the activity of Cdc2 in a phosphorylation-related manner. | Genistein | H3 histone pseudogene 16 | Homo sapiens |