Title : Dexrazoxane significantly impairs the induction of doxorubicin resistance in the human leukaemia line, K562.

Pub. Date : 2001 Apr 6

PMID : 11286477






3 Functional Relationships(s)
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1 Dexrazoxane combined with doxorubicin (+ 5-fluorouracil + cyclophosphamide - the FAC regime) leads to a significant decrease in doxorubicin cardiotoxicity and a significant increase in median survival time for patients with advanced breast cancer responsive to FAC. Dexrazoxane FA complementation group C Homo sapiens
2 Dexrazoxane combined with doxorubicin (+ 5-fluorouracil + cyclophosphamide - the FAC regime) leads to a significant decrease in doxorubicin cardiotoxicity and a significant increase in median survival time for patients with advanced breast cancer responsive to FAC. Dexrazoxane FA complementation group C Homo sapiens
3 These results suggest that dexrazoxane may delay the development of MDR1, thus allowing responders to the FAC regime to continue to respond. Dexrazoxane FA complementation group C Homo sapiens