Pub. Date : 2001 Apr 10
PMID : 11284688
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | The multidrug transporter P-glycoprotein (Pgp) is an ATPase efflux pump for multiple cytotoxic agents, including vinblastine and colchicine. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | The multidrug transporter P-glycoprotein (Pgp) is an ATPase efflux pump for multiple cytotoxic agents, including vinblastine and colchicine. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | The magnitude of the increase in UIC2 reactivity in the presence of saturating concentrations of colchicine correlates with the relative ability of Pgp to confer colchicine resistance in different cell lines, suggesting the existence of some cell-specific factors that have a coordinate effect on the ability of colchicine to induce conformational transitions and to be transported by Pgp. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | The magnitude of the increase in UIC2 reactivity in the presence of saturating concentrations of colchicine correlates with the relative ability of Pgp to confer colchicine resistance in different cell lines, suggesting the existence of some cell-specific factors that have a coordinate effect on the ability of colchicine to induce conformational transitions and to be transported by Pgp. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 9 | The magnitude of the increase in UIC2 reactivity in the presence of saturating concentrations of colchicine correlates with the relative ability of Pgp to confer colchicine resistance in different cell lines, suggesting the existence of some cell-specific factors that have a coordinate effect on the ability of colchicine to induce conformational transitions and to be transported by Pgp. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 10 | The magnitude of the increase in UIC2 reactivity in the presence of saturating concentrations of colchicine correlates with the relative ability of Pgp to confer colchicine resistance in different cell lines, suggesting the existence of some cell-specific factors that have a coordinate effect on the ability of colchicine to induce conformational transitions and to be transported by Pgp. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 11 | Colchicine increases the UIC2 reactivity and reverses the effect of ATP in ATPase-deficient Pgp mutants, but not in the wild-type Pgp expressed in the same cellular background, suggesting that ATP hydrolysis counteracts the effects of colchicine on the Pgp conformation. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |