Title : Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species.

Pub. Date : 2001 Mar 1

PMID : 11280728






5 Functional Relationships(s)
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1 The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to cytochrome c. Proline proline dehydrogenase 1 Homo sapiens
2 In cells expressing POX, the addition of proline increases reactive oxygen species (ROS) generation in a concentration-dependent manner; glutamate, a downstream product of proline oxidation, had no effect. Proline proline dehydrogenase 1 Homo sapiens
3 In cells expressing POX, the addition of proline increases reactive oxygen species (ROS) generation in a concentration-dependent manner; glutamate, a downstream product of proline oxidation, had no effect. Proline proline dehydrogenase 1 Homo sapiens
4 Again, we found a proline-dependent ROS increase with POX expression. Proline proline dehydrogenase 1 Homo sapiens
5 We hypothesize that proline oxidation supports the generation of ROS by donating reducing potential to an electron transport chain altered either by p53-dependent mechanisms or by overexpression of POX. Proline proline dehydrogenase 1 Homo sapiens