Pub. Date : 2001 Mar 1
PMID : 11280728
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to cytochrome c. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 2 | In cells expressing POX, the addition of proline increases reactive oxygen species (ROS) generation in a concentration-dependent manner; glutamate, a downstream product of proline oxidation, had no effect. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 3 | In cells expressing POX, the addition of proline increases reactive oxygen species (ROS) generation in a concentration-dependent manner; glutamate, a downstream product of proline oxidation, had no effect. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 4 | Again, we found a proline-dependent ROS increase with POX expression. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 5 | We hypothesize that proline oxidation supports the generation of ROS by donating reducing potential to an electron transport chain altered either by p53-dependent mechanisms or by overexpression of POX. | Proline | proline dehydrogenase 1 | Homo sapiens |