Title : Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species.

Pub. Date : 2001 Mar 1

PMID : 11280728






5 Functional Relationships(s)
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1 In cells expressing POX, the addition of proline increases reactive oxygen species (ROS) generation in a concentration-dependent manner; glutamate, a downstream product of proline oxidation, had no effect. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
2 In cells expressing POX, the addition of proline increases reactive oxygen species (ROS) generation in a concentration-dependent manner; glutamate, a downstream product of proline oxidation, had no effect. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
3 To confirm that the observed ROS production was not secondary to some other effect of p53, we also conditionally expressed POX in a p53-negative colon cancer line. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
4 Again, we found a proline-dependent ROS increase with POX expression. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
5 We hypothesize that proline oxidation supports the generation of ROS by donating reducing potential to an electron transport chain altered either by p53-dependent mechanisms or by overexpression of POX. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens