Title : Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

Pub. Date : 2001 Jun 15

PMID : 11279232






3 Functional Relationships(s)
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Protein Name
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1 The p70(S6K) phosphorylation at Ser(411) and Thr(421)/Ser(424) was inhibited by rapamycin, PD98059, or DNM-ERK2 but not by wortmannin, SB202190, DNM-Deltap85, or DNM-p38. Serine mitogen-activated protein kinase 1 Homo sapiens
2 The p70(S6K) phosphorylation at Ser(411) and Thr(421)/Ser(424) was inhibited by rapamycin, PD98059, or DNM-ERK2 but not by wortmannin, SB202190, DNM-Deltap85, or DNM-p38. Serine mitogen-activated protein kinase 1 Homo sapiens
3 In vitro assays indicated that Ser(411) on immunoprecipitated p70(S6K) proteins is phosphorylated by active JNKs and ERKs, but not p38 kinase, and Thr(421)/Ser(424) is phosphorylated by ERK1, but not ERK2, JNKs, or p38 kinase. Serine mitogen-activated protein kinase 1 Homo sapiens