Title : Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species.

Pub. Date : 2001 May 18

PMID : 11279018






1 Functional Relationships(s)
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1 Raising intracellular ROS by depletion of glutathione with buthionine sulfoximine (BSO) or glutamine starvation resulted in down-regulation of Pgp and p27Kip1, whereas ERK1,2 and JNK were activated. Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens