Title : Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport.

Pub. Date : 2001 May 11

PMID : 11278867






1 Functional Relationships(s)
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1 In addition, in contrast to wild-type MRP1, leukotriene C(4) transport by the W1246C-MRP1 protein was no longer inhibitable by E(2)17betaG, indicating that the mutant protein had lost the ability to bind the glucuronide. Glucuronides ATP binding cassette subfamily C member 1 Homo sapiens