Title : Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts.

Pub. Date : 2001 Jun 1

PMID : 11278846






2 Functional Relationships(s)
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1 Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. Sodium Salicylate CCAAT enhancer binding protein beta Homo sapiens
2 This study demonstrates that sodium salicylate at a therapeutic concentration suppressed COX-2 gene transcription induced by phorbol 12-myristate 13-acetate and interleukin 1beta by inhibiting the binding of CCAAT/enhancer-binding protein beta to its promoter region of COX-2. Sodium Salicylate CCAAT enhancer binding protein beta Homo sapiens