Title : Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway.

Pub. Date : 2001 May 11

PMID : 11278771






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Overexpression of dominant-negative JNK1 or a transactivating domain mutant of c-Jun significantly blocked the ability of TCA to down-regulate CYP7A1 mRNA. Taurocholic Acid cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus
2 In contrast, overexpression of wild-type c-Jun (c-Jun(wt)) enhanced the repression of CYP7A1 by TCA. Taurocholic Acid cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus