Title : Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300.

Pub. Date : 2001 Apr 13

PMID : 11278336






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Ligands of PPARgamma inhibited phorbol ester (phorbol 12-myristate 13-acetate, PMA)-mediated induction of COX-2 and prostaglandin E(2) synthesis. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
2 Ligands of PPARgamma inhibited phorbol ester (phorbol 12-myristate 13-acetate, PMA)-mediated induction of COX-2 and prostaglandin E(2) synthesis. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
3 PMA-mediated induction of COX-2 promoter activity was inhibited by PPARgamma ligands; this suppressive effect was prevented by overexpressing a dominant negative form of PPARgamma or a PPAR response element decoy oligonucleotide. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
4 Bisphenol A diglycidyl ether, a compound that binds to PPARgamma but lacks the ability to activate transcription, also inhibited PMA-mediated induction of AP-1 activity and COX-2. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens