Title : Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1.

Pub. Date : 2001 May 11

PMID : 11278263






1 Functional Relationships(s)
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1 We recently obtained evidence that treatment of human colon cancer cells with exisulind (sulindac sulfone) and related compounds induces apoptosis by activation of protein kinase G (PKG) and c-Jun kinase (JNK1). sulindac sulfone Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens