Title : Analgesic domains of interferon-alpha.

Pub. Date : 2001 Mar 26

PMID : 11277596






2 Functional Relationships(s)
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1 After the 36th Phe residue, which was located closely to the 122nd Tyr residue in the tertiary structure, was mutated to Ser using site-directed mutagenesis, the analgesic activity of this mutant lost completely, but the antiviral activity of IFNalpha still maintained 40.5% of wild type IFNalpha. Serine interferon alpha 1 Homo sapiens
2 After the 36th Phe residue, which was located closely to the 122nd Tyr residue in the tertiary structure, was mutated to Ser using site-directed mutagenesis, the analgesic activity of this mutant lost completely, but the antiviral activity of IFNalpha still maintained 40.5% of wild type IFNalpha. Serine interferon alpha 1 Homo sapiens