Title : Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation.

Pub. Date : 2001 Jul 6

PMID : 11274179






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Incubation of cells with nocodazole leads to activation of Pak1/2, kinases downstream of small GTPases Rac/Cdc42, which have been previously indicated to phosphorylate Raf-1 Ser(338). Nocodazole cell division cycle 42 Homo sapiens
2 Nocodazole-induced stimulation of Raf-1 is augmented by co-expression of small GTPases Rac/Cdc42 and Pak1/2. Nocodazole cell division cycle 42 Homo sapiens