Title : Butyrate alters the expression and activity of cell cycle components in anaplastic thyroid carcinoma cells.

Pub. Date : 2001 Jan

PMID : 11272092






2 Functional Relationships(s)
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1 Exposure to butyrate increases the expression of the cyclin-dependent kinase inhibitors, p21/Cip1 and p27/Kip1, decreases the expression of cyclin A and cyclin B, inhibits the phosphorylation of the retinoblastoma protein (pRb), and decreases the activity of cdk1 and cdk2-associated kinases. Butyrates cyclin dependent kinase inhibitor 1A Homo sapiens
2 Exposure to butyrate increases the expression of the cyclin-dependent kinase inhibitors, p21/Cip1 and p27/Kip1, decreases the expression of cyclin A and cyclin B, inhibits the phosphorylation of the retinoblastoma protein (pRb), and decreases the activity of cdk1 and cdk2-associated kinases. Butyrates cyclin dependent kinase inhibitor 1A Homo sapiens