Title : Differing effects of two nitric oxide synthase inhibitors on experimental colitis.

Pub. Date : 2001 Jan-Feb

PMID : 11268945






2 Functional Relationships(s)
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1 Exposure to the trinitrobenzene sulfonic acid enema inhibited the increase in body weight of rats, and markedly increased the colonic damage scores, wet weight, thiobarbituric acid-reactive substances and myeloperoxidase activity. Trinitrobenzenesulfonic Acid myeloperoxidase Rattus norvegicus
2 The increases in the colonic damage scores, wet weight, thiobarbituric acid-reactive substances and myeloperoxidase activity in trinitrobenzene sulfonic acid-colitis were significantly inhibited by aminoguanidine treatment, although they tended to be aggravated by NG-nitro-L-arginine treatment. Trinitrobenzenesulfonic Acid myeloperoxidase Rattus norvegicus