Title : ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.

Pub. Date : 2001 Mar

PMID : 11266364






2 Functional Relationships(s)
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1 Here we show that by deleting ASK1 in mice, TNF- and H(2)O(2)-induced sustained activations of JNK and p38 are lost in ASK1(-/-) embryonic fibroblasts, and that ASK1(-/-) cells are resistant to TNF- and H(2)O(2)-induced apoptosis. Hydrogen Peroxide tumor necrosis factor Mus musculus
2 Here we show that by deleting ASK1 in mice, TNF- and H(2)O(2)-induced sustained activations of JNK and p38 are lost in ASK1(-/-) embryonic fibroblasts, and that ASK1(-/-) cells are resistant to TNF- and H(2)O(2)-induced apoptosis. Hydrogen Peroxide tumor necrosis factor Mus musculus