Title : Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.

Pub. Date : 2001 Jun 8

PMID : 11262417






1 Functional Relationships(s)
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1 The compounds were screened for their ability to activate CFTR at 50 microm concentration by measurement of the kinetics of iodide influx in Fisher rat thyroid cells expressing wild-type or G551D CFTR together with the green fluorescent protein-based halide indicator YFP-H148Q. Iodides CF transmembrane conductance regulator Homo sapiens