Title : MDM2 gene amplification and lack of p53 point mutations in Hodgkin and Reed-Sternberg cells: results from single-cell polymerase chain reaction and molecular cytogenetic studies.

Pub. Date : 2001 Mar

PMID : 11260082






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 As gene amplification is frequently associated with protein overexpression, the observed accumulation of p53 in the nuclei of H & RS cells could be as a result of elevated MDM2 protein levels resulting in stabilization of p53 protein. Adenosine Monophosphate tumor protein p53 Homo sapiens