Pub. Date : 2001 Mar
PMID : 11260059
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Myristoylated alanine-rich C kinase substrate phosphorylation is involved in thrombin-induced serotonin release from platelets. | Serotonin | coagulation factor II, thrombin | Homo sapiens |
| 2 | Stimulation of platelets by thrombin induces protein kinase C (PKC) activation, phosphorylation of pleckstrin, aggregation and serotonin release. | Serotonin | coagulation factor II, thrombin | Homo sapiens |
| 3 | Here, we demonstrate that, in human platelets, thrombin stimulation also induced phosphorylation of the myristoylated alanine-rich C kinase substrate (MARCKS) and serotonin release in intact and digitonin-permeabilized platelets. | Serotonin | coagulation factor II, thrombin | Homo sapiens |
| 4 | MARCKS phosphorylation and serotonin release in response to increasing concentrations of thrombin have a similar EC50 and time course and, in permeabilized platelets, peptide MPSD, with an amino acid sequence corresponding to the phosphorylation site domain of MARCKS, blocked both responses. | Serotonin | coagulation factor II, thrombin | Homo sapiens |