Title : Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation.

Pub. Date : 2000 Nov

PMID : 11258483






2 Functional Relationships(s)
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1 We further demonstrate that co-expression of a constitutively active NFAT and a constitutively active MEKK1 renders the interleukin-2 promoter in Jurkat T lymphocytes resistant to CsA and FK506, whereas Jurkat cells expressing a constitutively active NFAT alone are still sensitive to CsA or FK506. Tacrolimus interleukin 2 Homo sapiens
2 We further demonstrate that co-expression of a constitutively active NFAT and a constitutively active MEKK1 renders the interleukin-2 promoter in Jurkat T lymphocytes resistant to CsA and FK506, whereas Jurkat cells expressing a constitutively active NFAT alone are still sensitive to CsA or FK506. Tacrolimus interleukin 2 Homo sapiens